Lotusine

Lotusine is an alkaloid that has been found in N. nucifera and has diverse biological activities. It increases the level of cAMP in rat myocardium when used at concentrations ranging from 0.1 to 3 µM and the levels of cGMP in rabbit corpus cavernosum in a concentration-dependent manner. Lotusine prevents lipid peroxidation induced by doxorubicin (Cay-15007) in H9c2 embryonic rat cardiomyocytes. It also increases left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), and systolic arterial blood pressure (SAP) in anesthetized rats when administered at a dose of 5 mg/kg.Formal Name: (1R)-1,2,3,4-tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-isoquinolinium. CAS Number: 6871-67-6. Synonyms: (-)-Lotusine. Molecular Formula: C19H24NO3. Formula Weight: 314.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 230 nm. SMILES: OC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3OC. InChi Code: InChI=1S/C19H23NO3/c1-20(2)9-8-14-11-18(22)19(23-3)12-16(14)17(20)10-13-4-6-15(21)7-5-13/h4-7,11-12,17H,8-10H2,1-3H3,(H-,21,22)/p+1/t17-/m1/s1. InChi Key: ZKTMLINFIQCERN-QGZVFWFLSA-O. Origin: Plant/Nelumbo nucifera.