Latrunculin A

Latrunculin A
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10010630-25 25 µg -

6 - 10 Werktage*

66,00 €
Cay10010630-50 50 µg -

6 - 10 Werktage*

123,00 €
Cay10010630-100 100 µg -

6 - 10 Werktage*

180,00 €
 
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in... mehr
Produktinformationen "Latrunculin A"
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 µM) and in cells (0.5 µM, 30 min).{ Latrunculin A (1-10 µM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 µM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability.Formal Name: (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone. CAS Number: 76343-93-6. Synonyms: NSC 613011. Molecular Formula: C22H31NO5S. Formula Weight: 421.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. SMILES: C/C(CC/C=C/C=C\[C@@H](C)CC[C@@H]1C[C@@H]2C[C@@]([C@H]3NC(SC3)=O)(O)O1)=C/C(O2)=O. InChi Code: InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1. InChi Key: DDVBPZROPPMBLW-IZGXTMSKSA-N.
Schlagworte: NSC 613011, (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone
Hersteller: Cayman Chemical
Hersteller-Nr: 10010630

Eigenschaften

Anwendung: Actin polymerization inhibitor
MW: 421.6 D
Formel: C22H31NO5S
Reinheit: >95%
Format: Solution

Datenbank Information

CAS : 76343-93-6| Passende Produkte
KEGG ID : K05692 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H319, H333
P-Sätze: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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