Hydroxychloroquine (sulfate)

Hydroxychloroquine (sulfate)
COVID-19 Forschung
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay17911-25 25 mg -

6 - 10 Werktage*

43,00 €
Cay17911-50 50 mg -

6 - 10 Werktage*

60,00 €
Cay17911-100 100 mg -

6 - 10 Werktage*

109,00 €
Cay17911-250 250 mg -

6 - 10 Werktage*

246,00 €
 
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral... mehr
Produktinformationen "Hydroxychloroquine (sulfate)"
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities. It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM). Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) and ionomycin (Cay-10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner. Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques. Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.Formal Name: 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol, monosulfate. CAS Number: 747-36-4. Synonyms: HCQ, NSC 4375. Molecular Formula: C18H26ClN3O . H2SO4. Formula Weight: 434.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. lambdamax: 221, 236, 256, 329, 343 nm. SMILES: CC(CCCN(CC)CCO)NC1=CC=NC2=CC(Cl)=CC=C21.O=S(O)(O)=O. InChi Code: InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18,1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21),(H2,1,2,3,4). InChi Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N.
Schlagworte: HCQ, NSC 4375, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol, monosulfate
Hersteller: Cayman Chemical
Hersteller-Nr: 17911

Eigenschaften

Anwendung: Antimalarial, Lupus erythematosus suppressant
MW: 434 D
Formel: C18H26ClN3O . H2SO4
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 747-36-4| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H319
P-Sätze: P264, P270, P280, P301+310, P305+351+338, P330, P337+313, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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COVID-19 Forschung
Hydroxychloroquine . sulfate Hydroxychloroquine . sulfate
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