GRL-0617

GRL-0617 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 papain-like proteases (PLpros, IC50s = 0.6 and 1.5 µM, respectively). It increases the viability of SARS-CoV-infected Vero E6 cells (EC50 = 14.5 µM). GRL-0617 (6.25-50 µM) reduces viral replication in SARS-CoV-2-infected Caco-2 cells.Formal Name: 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-benzamide. CAS Number: 1093070-16-6. Molecular Formula: C20H20N2O. Formula Weight: 304.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 224 nm. SMILES: O=C(C1=C(C=CC(N)=C1)C)N[C@@H](C2=CC=CC3=C2C=CC=C3)C. InChi Code: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1. InChi Key: UVERBUNNCOKGNZ-CQSZACIVSA-N.