Gö 6976

Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCalpha and PKCbeta1, respectively. It does not inhibit the activity of PKCdelta, PKCepsilon, or PKCzeta (IC50s > 3 µM), indicating a preference for the Ca2+-dependent subtypes, PKCalpha and PKCbeta1. Gö 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.Formal Name: 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile. CAS Number: 136194-77-9. Synonyms: PD 406976. Molecular Formula: C24H18N4O. Formula Weight: 378.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7) (1:10): 0.1 mg/ml, DMSO: 10 mg/ml. lambdamax: 245, 290, 332, 367 nm. SMILES: O=C1NCC2=C3C(N(CCC#N)C4=CC=CC=C43)=C5C(C6=CC=CC=C6N5C)=C21. InChi Code: InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29). InChi Key: VWVYILCFSYNJHF-UHFFFAOYSA-N.