Fenofibrate

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10005368-1000 1 g -

6 - 10 Werktage*

19,00 €
 
Fenofibrate is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) with... mehr
Produktinformationen "Fenofibrate"
Fenofibrate is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) with EC50 values of 18 and 30 µM for mouse and human receptors, respectively, in a transactivation assay. It is selective for PPARalpha over PPARgamma (EC50s = 300 and 200 µM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARdelta at a concentration of 100 µM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner. It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Cay-13119) in rat kidney when administered at a dose of 100 mg/kg. Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.Formal Name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester. CAS Number: 49562-28-9. Molecular Formula: C20H21ClO4. Formula Weight: 360.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml. lambdamax: 287 nm. SMILES: ClC1=CC=C(C(C2=CC=C(OC(C)(C(OC(C)C)=O)C)C=C2)=O)C=C1. InChi Code: InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3. InChi Key: YMTINGFKWWXKFG-UHFFFAOYSA-N.
Schlagworte: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester
Hersteller: Cayman Chemical
Hersteller-Nr: 10005368

Eigenschaften

Anwendung: PPARalpha agonist
MW: 360.8 D
Formel: C20H21ClO4
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 49562-28-9| Passende Produkte
KEGG ID : K07294 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H312, H332, H361, H373, H413
P-Sätze: P201, P202, P260, P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P308+313, P312, P314, P321, P330, P361+364, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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