Ezetimibe

Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the levels of helper T cells and memory T cells isolated from the blood of heart transplant recipients. Formulations containing ezetimibe have been used in the treatment of primary hypercholesterolemia and mixed hyperlipidemia.Formal Name: (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. CAS Number: 163222-33-1. Synonyms: Ezetrol, SCH 58235. Molecular Formula: C24H21F2NO3. Formula Weight: 409.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 233 nm. SMILES: OC(C=C1)=CC=C1[C@@H]2[C@@H](CC[C@H](O)C3=CC=C(F)C=C3)C(N2C4=CC=C(F)C=C4)=O. InChi Code: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1. InChi Key: OLNTVTPDXPETLC-XPWALMASSA-N.