DMXAA

DMXAA
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14617-1 1 mg -

6 - 10 Werktage*

43,00 €
Cay14617-5 5 mg -

6 - 10 Werktage*

94,00 €
Cay14617-10 10 mg -

6 - 10 Werktage*

164,00 €
Cay14617-25 25 mg -

6 - 10 Werktage*

358,00 €
 
DMXAA is a xanthene which acts as a tumor vascular disrupting agent, inducing apoptosis in tumor... mehr
Produktinformationen "DMXAA"
DMXAA is a xanthene which acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 (TBK1/IRF3) signaling pathway in leukocytes, inducing type-I-interferon (IFN) production. Specifically, DMXAA activates the mitochondria- and endoplasmic reticulum-associated protein known as stimulator of interferon genes (STING), leading to TBK1/IRF3 signaling. DMXAA signals through mouse STING but not human STING. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC50 = 119 and 11 µM, respectively).Formal Name: 5,6-dimethyl-9-oxo-9H-xanthene-4-acetic acid. CAS Number: 117570-53-3. Synonyms: ASA 404, 5,6-Dimethylxanthenone-4-acetic Acid, NSC 640488, Vadimezan. Molecular Formula: C17H14O4. Formula Weight: 282.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml, DMSO: 1 mg/ml. SMILES: O=C1C2=C(C(CC(O)=O)=CC=C2)OC3=C(C)C(C)=CC=C31. InChi Code: InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19). InChi Key: XGOYIMQSIKSOBS-UHFFFAOYSA-N.
Schlagworte: 5,6-Dimethylxanthenone-4-acetic Acid, ASA 404, NSC 640488, Vadimezan, 5,6-dimethyl-9-oxo-9H-xanthene-4-acetic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 14617

Eigenschaften

Anwendung: VEGFR2 inhibitor, Apoptosis inducer
MW: 282.3 D
Formel: C17H14O4
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 117570-53-3| Passende Produkte
KEGG ID : K05098 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H400
P-Sätze: P264, P270, P273, P301+310, P330, P391, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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