CP 424,174

CP 424,174 is an inhibitor of stimulus-coupled IL-1beta post-translational processing. It inhibits ATP-induced proteolytic cleavage of pro-IL-1beta, measured by secretion of the 17 kDa mature form of IL-1beta, in LPS-primed human blood-derived monocytes when used at concentrations of 0.5 and 2.5 µM. CP 424,174 inhibits ATP-induced IL-1alpha and IL-1beta production in LPS-primed mouse peritoneal macrophages (ED50s = 15 and 14 mg/kg, respectively).Formal Name: N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-benzenesulfonamide. CAS Number: 210825-31-3. Molecular Formula: C22H29ClN2O4S. Formula Weight: 453.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml. SMILES: CC(C)C1=C(NC(NS(C2=CC(C(C)(O)C)=CC=C2)(=O)=O)=O)C(C(C)C)=CC(Cl)=C1. InChi Code: InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26). InChi Key: YRSBLSHMKVQWHP-UHFFFAOYSA-N.