CAY10621

CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM.Formal Name: (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester. CAS Number: 120005-55-2. Synonyms: SKI 5C, SPHK1 Inhibitor 5C. Molecular Formula: C26H45NO4. Formula Weight: 435.6. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 3 mg/ml, DMSO: 2 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 224 nm. SMILES: CCCCCCCCCCCCCCCC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C. InChi Code: InChI=1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m1/s1. InChi Key: YGBSGZPIDCXNEH-JOCHJYFZSA-N.