BLU-667

BLU-667 is an inhibitor of the rearranged during transfection (RET) kinase. RET is an oncogenic driver activated in multiple cancers. BLU-667 is an early selective small molecule designed to target RET, in contrast with current treatment methods that have been limited to multikinase inhibitors. BLU-667 potently inhibits growth of RET-driven non-small cell lung cancer and thyroid cancer xenografts in vtiro. SMILES: Cc1[nH]nc(c1)Nc2nc(nc(c2)C)[C@H]3CC[C@@](CC3)(OC)C(=O)N[C@H](c4cnc(cc4)n5ncc(c5)F)C