Sorafenib

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10009644-5 5 mg -

6 - 10 Werktage*

43,00 €
Cay10009644-10 10 mg -

6 - 10 Werktage*

65,00 €
Cay10009644-25 25 mg -

6 - 10 Werktage*

146,00 €
Cay10009644-50 50 mg -

6 - 10 Werktage*

246,00 €
 
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM,... mehr
Produktinformationen "Sorafenib"
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1, MEK1, EGFR, and HER2 (IC50s = >10 µM for all). Sorafenib inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively) and induces apoptosis in these cells. It completely inhibits tumor growth in a PLC/PRF/5 mouse xenograft model when administered at a dose of 30 mg/kg and reduces basic FGF-induced angiogenesis in a Matrigel(TM) assay in vivo. Sorafenib (10 µM) induces ferroptotic cell death in HT-1080 fibrosarcoma cells, an effect that can be blocked by the ferroptosis inhibitors ferrostatin-1 (Cay-17729), deferoxamine (Cay-14595), and beta-mercaptoethanol, but does not induce ferroptosis in a variety of other cancer cell lines. It inhibits glutamate release by the system xc- cystine/glutamate transporter in HT-1080 cells when used at concentrations ranging from 2.5 to 10 µM, decreases glutathione levels, and increases lipid peroxidation. Sorafenib also inhibits replication of hepatitis C virus (HCV) in Huh7.5 cells (IC50 = 7.2 µM). Formulations containing sorafenib have been used in the treatment of hepatocellular, renal cell, and thyroid carcinomas.Formal Name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide. CAS Number: 284461-73-0. Synonyms: BAY 43-9006. Molecular Formula: C21H16ClF3N4O3. Formula Weight: 464.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 204, 266 nm. SMILES: O=C(NC)C1=NC=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=C1. InChi Code: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31). InChi Key: MLDQJTXFUGDVEO-UHFFFAOYSA-N.
Schlagworte: BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Hersteller: Cayman Chemical
Hersteller-Nr: 10009644

Eigenschaften

Anwendung: Kinase inhibitor
MW: 464.8 D
Formel: C21H16ClF3N4O3
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 284461-73-0| Passende Produkte
KEGG ID : K04366 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H351, H360, H362, H372, H400, H410
P-Sätze: P201, P202, P260, P263, P264, P270, P273, P280, P308+313, P314, P391, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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