ARM1

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Cay-20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.Formal Name: 4-[4-(phenylmethyl)phenyl]-2-thiazolamine. CAS Number: 68729-05-5. Molecular Formula: C16H16N2S. Formula Weight: 268.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 1mg/ml. lambdamax: 236, 285, 344 nm. SMILES: NC(N1)=SC=C1C(C=C2)=CC=C2CC3=CC=CC=C3. InChi Code: InChI=1S/C16H16N2S/c17-16-18-15(11-19-16)14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9,11,18-19H,10,17H2. InChi Key: CEXYUVBVAHGQJI-UHFFFAOYSA-N.