AN3365 (hydrochloride)

AN3365 is an inhibitor of leucyl-tRNA synthetase (LeuRS, IC50 = 0.31 µM for the E. coli enzyme). It is active against a variety of Gram-negative and Gram-positive bacteria, including E. coli, E. faecalis, S. epidermidis, S. pneumoniae, and S. pyogenes (MICs = 4, 8, 2, 2, and 2 µg/ml, respectively), as well as a panel of multidrug-resistant (MDR) clinical isolates of the Gram-negative bacteria A. baumannii, Enterobacteriaceae, and P. aeruginosa (MICs = 0.5-4, 0.5-2, and 1-4 µg/ml, respectively). AN3365 inhibits protein, RNA, DNA, and fatty acid synthesis in E. coli (IC50s = 8.3, 105, 366, and 396 µg/ml, respectively). It reduces the number of colony forming units (CFUs) in neutropenic mouse thigh models of E. coli or P. aeruginosa infection when administered at a dose of 30 mg/kg.Formal Name: 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride. CAS Number: 1234563-16-6. Synonyms: Epetraborole, GSK2251052. Molecular Formula: C11H16BNO4 . HCl. Formula Weight: 273.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. lambdamax: 230, 284 nm. SMILES: OB1O[C@H](CN)C2=CC=CC(OCCCO)=C21.Cl. InChi Code: InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10,/h1,3-4,10,14-15H,2,5-7,13H2,1H/t10-,/m1./s1. InChi Key: DADYQGIQOBJGIW-HNCPQSOCSA-N.