Amorolfine hydrochloride

White powder. Soluble in ethanol (20mg/ml), DMSO (5mg/ml) or PBS, pH7.2 (10mg/ml). Chemical. CAS: 78613-38-4. Formula: C21H35ON . HCl. MW: 317.51 . 36.46. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.