ADP-TAMRA conjugate [5-TAMRA-eda-ADP]

ADP-TAMRA conjugate [5-TAMRA-eda-ADP]
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABD-13606 100 nmol -

3 - 8 Werktage*

580,00 €
Fluorescently labeled ADP molecules are used to screening ADP-binding enzymes and other protein... mehr
Produktinformationen "ADP-TAMRA conjugate [5-TAMRA-eda-ADP]"
Fluorescently labeled ADP molecules are used to screening ADP-binding enzymes and other protein targets for drug discovery. This ADP-TAMRA has been tested for binding kynurenine monooxygenase (KMO) with a K(d) value of 0.60 ± 0.05 ?M and to the NMOs from Aspergillus fumigatus and Mycobacterium smegmatis with K(d) values of 2.1 ± 0.2 and 4.0 ± 0.2 µM, respectively (Anal Biochem. 2012, 425, 80-7). The assay was tested in competitive binding experiments with substrates and products of KMO and an NMO. NMOs are essential for pathogenesis in fungi and bacteria. NMOs catalyze the hydroxylation of sine and ornithine in the biosynthesis of hydroxamate-containing siderophores. Inhibition of KMO, which catalyzes the conversion of kynurenine to 3-hydroxykynurenine, alleviates neurodegenerative disorders such as Huntington's and Alzheimer's diseases and brain infections caused by the parasite Trypanosoma brucei.
Hersteller: AAT Bioquest
Hersteller-Nr: 13606


Anwendung: ADP-binding protein screening, Drug discovery
MW: 925,73 D
Format: Desiccated

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C (protect from light)
Versand: -20°C (International: -20°C)
Signalwort: Warning
P-Sätze: P304, P312
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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