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Artikelnummer: Cay10010206-5
Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP. BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki...
Schlagworte: | A-FABP Inhibitor, Adipocyte FABP Inhibitor, ALBP Inhibitor, aP2 Inhibitor, FABP4 Inhibitor, Fatty Acid Binding Protein 4... |
Anwendung: | Cell-permeable, potent FABP4 inhibitor |
CAS | 300657-03-8 |
MW: | 474.6 D |
ab 60,00 €
Artikelnummer: Cay11914-1
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...
Schlagworte: | Smoothened Agonist,... |
Anwendung: | Smo Agonist |
CAS | 912545-86-9 |
MW: | 490.1 D |
ab 48,00 €
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
Anwendung: | Estrogen receptor modulator |
CAS | 10540-29-1 |
MW: | 371.5 D |
ab 77,00 €
Artikelnummer: Cay10010630-100
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
Schlagworte: | NSC 613011,... |
Anwendung: | Actin polymerization inhibitor |
CAS | 76343-93-6 |
MW: | 421.6 D |
ab 66,00 €
Artikelnummer: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
Schlagworte: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
Anwendung: | Calcium ionophore |
CAS | 56092-82-1 |
MW: | 747.1 D |
ab 44,00 €
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
Anwendung: | AMPK activator |
CAS | 1115-70-4 |
MW: | 165.6 D |
ab 31,00 €
Artikelnummer: Cay15218-10
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
Schlagworte: | Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
Anwendung: | Inhibits mitochondrial oxidative phosphorylation, uncoupling reagent |
CAS | 370-86-5 |
MW: | 254.2 D |
ab 88,00 €
Artikelnummer: Cay80310-10
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
Schlagworte: | N6-(1-iminoethyl)-L-lysine, dihydrochloride |
Anwendung: | iNOS inhibitor |
CAS | 159190-45-1 |
MW: | 260.2 D |
ab 54,00 €
Artikelnummer: Cay82120-10
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
Schlagworte: | Diethylenetriamine NONOate, NOC-18, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate |
Anwendung: | NO donor |
CAS | 146724-94-9 |
MW: | 163.2 D |
ab 50,00 €
Artikelnummer: Cay9002863-50
Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns. The...
Schlagworte: | DSSO, 3,3'-sulfinylbis-propanoic acid, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester |
Anwendung: | Protein cross-linking probe |
CAS | 1351828-03-9 |
MW: | 388.3 D |
ab 54,00 €
Artikelnummer: LKT-N3476.50
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Schlagworte: | NTBC, orfadin |
Anwendung: | 4-hydroxyphenylpyruvate dioxygenase inhibitor |
CAS | 104206-65-7 |
MW: | 329.23 D |
ab 80,00 €
Artikelnummer: Cay11046-1
2-NBDG is a fluorescent derivative of glucose whose uptake is competitively inhibited by D-glucose (Cay-23733), but not L-glucose (Cay-20829) or sucrose, in E. coli. It has been used to monitor glucose uptake by bacteria and live mammalian cells and in tumor biopsies. 2-NBDG displays excitation/emission maxima of...
Schlagworte: | NBD-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose |
Anwendung: | Deoxyglucose analog |
CAS | 186689-07-6 |
MW: | 342.3 D |
ab 49,00 €