3,4-Dichloroisocoumarin

3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.Formal Name: 3,4-dichloro-1H-2-benzopyran-1-one. CAS Number: 51050-59-0. Synonyms: 3,4-DCI. Molecular Formula: C9H4Cl2O2. Formula Weight: 215.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 233, 248, 273, 283, 326 nm. SMILES: ClC1=C(Cl)OC(C2=C1C=CC=C2)=O. InChi Code: InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H. InChi Key: SUGXUUGGLDCZKB-UHFFFAOYSA-N.