Tunicamycin

Tunicamycin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay11445-1 1 mg -

5 - 10 Werktage*

32,00 €
Cay11445-5 5 mg -

5 - 10 Werktage*

87,00 €
Cay11445-10 10 mg -

5 - 10 Werktage*

157,00 €
 
Tunicamycin mixture is a mixture of tunicamycins with variable trans-2,3-unsaturated branched... mehr
Produktinformationen "Tunicamycin"
Tunicamycin mixture is a mixture of tunicamycins with variable trans-2,3-unsaturated branched chain fatty acid (BFCA) chain lengths. Tunicamycins are anti-microbial agents that are active against Gram-positive bacteria, fungi, and viruses. They inhibit the N-acetylhexosamine (HexNAc) phosphotransferase family of enzymes in bacteria and prevent peptidoglycan biosynthesis. In eukaryotes, they inhibit N-acetylglucosamine (GlcNAc) phosphotransferase (GPT), preventing the first step in N-linked glycosylation and inducing the unfolded protein response and cell death. The cellular toxicity of tunicamycins is linked to the trans-2,3-unsaturated BCFA, and saturated BCFA-containing tunicamycin derivatives, such as TunR1 (Cay-31537) and TunR2 (Cay-31538), have reduced toxicity. Tunicamycins impair glycosylation of the receptor tyrosine kinases EGFR, HER2, HER3, and IGF-1R, which prevents their translocation out of the endoplasmic reticulum and Golgi apparatus and reduces their protein levels and activity. Tunicamycin sensitizes EGFR inhibitor-resistant U251 glioma and Bx/PC-3 pancreatic adenocarcinoma cells to irradiation. CAS Number: 11089-65-9. Molecular Formula: C39H64N4O16 (for Tunicamycin VII). Formula Weight: 845.0. Purity: >95% (mixture of congeners). Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 208, 260 nm. SMILES: O=C1C=CN([C@@H]2O[C@H]([C@H](O)C[C@H]3O[C@@H](O[C@@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@H](NC(/C=C/[(CH2)n]C(C)C)=O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)C(N1)=O.
Hersteller: Cayman Chemical
Hersteller-Nr: 11445

Eigenschaften

Anwendung: N-glycosylation inhibitor
MW: 845 D
Formel: C39H64N4O16 (for Tunicamycin VII)
Reinheit: >95% (mixture of congeners)
Format: Crystalline Solid

Datenbank Information

CAS : 11089-65-9| Finde Alternativen
KEGG ID : K01001 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H300
P-Sätze: P264, P270, P301+310, P321, P330, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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