Siomycin A

Siomycin A
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay15378-500 500 µg -

6 - 10 Werktage*

530,00 €
 
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with... mehr
Produktinformationen "Siomycin A"
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 µM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.Formal Name: N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide, (1->528)-lactone. CAS Number: 12656-09-6. Synonyms: NSC 285116. Molecular Formula: C71H81N19O18S5. Formula Weight: 1648.9. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble. SMILES: O=C(NC(C(NC(C(N[C@@H](C)C(N[C@@]1(CCC(C2=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS2)=N[C@]1([H])C3=CSC4=N3)C5=NC(C(NC(C(N/C(C6=NC(C(N[C@@](C7=NC8=CS7)([H])[C@@]([C@H](O)C)(O)C)=O)CS6)=C\C)=O)[C@H](O)C)=O)=CS5)=O)=O)=C)=O)=C)[C@H](C(C)C)NC9C(O)C%10=NC(C(O[C@H](C)[C@]4([H])NC8=O)=O)=CC([C@@H](O)C)=C%10C=C9. InChi Code: InChI=1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)/b37-14-/t30-,31-,32+,33+,34+,38?,44?,46-,47?,48-,50?,51+,52+,70+,71+/m0/s1. InChi Key: AKFVOKPQHFBYCA-OFENGFFDSA-N. Origin: Bacterium/Streptomyces sp..
Schlagworte: NSC 285116, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a
Hersteller: Cayman Chemical
Hersteller-Nr: 15378

Eigenschaften

Anwendung: FoxM1 expression inhibitor
MW: 1648.9 D
Formel: C71H81N19O18S5
Reinheit: >85%
Format: Solid

Datenbank Information

CAS : 12656-09-6| Passende Produkte
KEGG ID : K09406 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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