Rapamycin

Rapamycin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay13346-1 1 mg -

6 - 10 Werktage*

50,00 €
Cay13346-5 5 mg -

6 - 10 Werktage*

115,00 €
Cay13346-10 10 mg -

6 - 10 Werktage*

185,00 €
Cay13346-25 25 mg -

6 - 10 Werktage*

432,00 €
 
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1... mehr
Produktinformationen "Rapamycin"
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml. It also induces autophagy in a variety of cell types. Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM. Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.Formal Name: (7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone. CAS Number: 53123-88-9. Synonyms: AY 22989, NSC 226080, Sirolimus, Wy 090217. Molecular Formula: C51H79NO13. Formula Weight: 914.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 268, 278, 289 nm. SMILES: O=C([C@]1([H])CCCCN1C(C([C@@]2(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C3)C)([H])O2)=O)=O)O[C@](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@@H]3C)=O)=O)([H])[C@H](C)C[C@H]4C[C@@H](OC)[C@H](O)CC4. InChi Code: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,. InChi Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N. Origin: Bacterium/Streptomyces hygroscopicus.
Schlagworte: AY 22989, NSC 226080, Wy 090217, (7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epo
Hersteller: Cayman Chemical
Hersteller-Nr: 13346

Eigenschaften

Anwendung: mTORC1 blocking
MW: 914.2 D
Formel: C51H79NO13
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 53123-88-9| Passende Produkte
KEGG ID : K07203 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H351, H361, H372
P-Sätze: P201, P202, P260, P264, P270, P280, P308+313, P314, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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