Puromycin (hydrochloride)

Puromycin (hydrochloride)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay13884-25 25 mg -

6 - 10 Werktage*

50,00 €
Cay13884-50 50 mg -

6 - 10 Werktage*

84,00 €
Cay13884-100 100 mg -

6 - 10 Werktage*

146,00 €
Cay13884-500 500 mg -

6 - 10 Werktage*

568,00 €
 
Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein... mehr
Produktinformationen "Puromycin (hydrochloride)"
Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains. A portion of the puromycin molecule resembles the 3' end of aminoacylated tRNA. It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl transferase center, causing the formation of a puromycylated nascent chain and premature chain release. The 3' position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome. These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems.Formal Name: 3'-[[2S-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine, dihydrochloride. CAS Number: 58-58-2. Synonyms: CL 13,900, CL 16,536, NSC 3055, PDH. Molecular Formula: C22H29N7O5 . 2HCl. Formula Weight: 544.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217, 276 nm. SMILES: O[C@H]([C@@H]1NC([C@@H](N)CC2=CC=C(OC)C=C2)=O)[C@@H](O[C@@H]1CO)N3C(N=CN=C4N(C)C)=C4N=C3.Cl.Cl. InChi Code: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12,,/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32),2*1H/t14-,15+,16+,18+,22+,,/m0../s1. InChi Key: MKSVFGKWZLUTTO-FZFAUISWSA-N.
Schlagworte: CL 13,900, CL 16,536, NSC 3055, PDH, 3'-[[2S-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine, dihydrochloride
Hersteller: Cayman Chemical
Hersteller-Nr: 13884

Eigenschaften

Anwendung: Aminonucleosid antibiotic
MW: 544.4 D
Formel: C22H29N7O5 . 2HCl
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 58-58-2| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302
P-Sätze: P264, P270, P330, P301+P310, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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