Biapenem

Biapenem is a broad-spectrum beta-lactam antibiotic. It is active against aerobic and anaerobic, Gram-positive and Gram-negative bacteria, including clinical isolates of E. coli, oxacillin-sensitive S. aureus, B. fragilis, and Clostridium (MIC90s = 0.12, 0.12, 0.25, and 1 µg/ml, respectively). It is also active against the rifampicin-susceptible H37Rv and rifampicin-resistant 115R and 124R M. tuberculosis strains (MICs = 2-4, 4-8, and 8-16 mg/L, respectively). Biapenem (200 mg/kg) decreases the number of lung colony-forming units (CFUs) in a mouse model of late-phase acute H37Rv M. tuberculosis infection.Formal Name: 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium, inner salt. CAS Number: 120410-24-4. Synonyms: CL 186815, LJC 10,627. Molecular Formula: C15H18N4O4S. Formula Weight: 350.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. lambdamax: 296 nm. SMILES: O=C1[C@@]([C@H](O)C)([H])[C@@]2([H])[C@@H](C)C(SC(C3)CN4[N+]3=CN=C4)=C(C([O-])=O)N21. InChi Code: InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1. InChi Key: MRMBZHPJVKCOMA-YJFSRANCSA-N.