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ODN 1668 (Type B) Endotoxin-free (sterile)
Artikelnummer: IAX-200-001-M001
3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1720 (Cat. No.: IAX-200-200).
| Schlagworte: | CpG ODN TLR9 Agonist: B Type (species: rodent) |
| Anwendung: | TLR9 activator |
| MW: | 6383 D |
ab 218,00 €
Amphotericin B (Fungizone) Solution, 100X
Artikelnummer: A2230.100
Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is...
| CAS | 1397-89-3 |
| MW: | 924.09 D |
ab 98,00 €
Isopropyl-beta-D-thiogalacto- pyranoside (IPTG)
Artikelnummer: 05684.25
Purity: >99%. Free of dioxane and other solvents. For use im molecular biology. In combination with X-Gal (cat# 02249) it is used to detect lac+ colonies in cloning experiments.
| Anwendung: | Inducer of beta-galactosidase |
| CAS | 367-93-1 |
| MW: | 238.30 |
ab 116,00 €
MES, ultra pure
Artikelnummer: 06010.100
MES (2-(N-morpholino)ethanesulfonic acid) is used as a buffering agent. It has pKa value of 6.15 at 20°C. The pH (and pKa at ionic strength I?0) of the buffer solution changes with concentration and temperature. MES is highly soluble in water. The melting point is approx. 300 °C. MOPS is a similar pH buffering...
| CAS | 4432-31-9 |
| MW: | 195.24 |
ab 76,00 €
D-Luciferin, sodium salt *UltraPure Grade*
Artikelnummer: ABD-12511
Luciferin is the most popular and versatile bioluminescent substrate.
| Anwendung: | Bioluminescence assays |
| CAS | 103404-75-7 |
ab 108,00 €
Y-27632 (hydrochloride)
Artikelnummer: Cay10005583-10
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50...
| Schlagworte: | 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride |
| Anwendung: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.3 D |
ab 77,00 €
BMS309403
Artikelnummer: Cay10010206-5
Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP. BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki...
| Schlagworte: | A-FABP Inhibitor, Adipocyte FABP Inhibitor, ALBP Inhibitor, aP2 Inhibitor, FABP4 Inhibitor, Fatty Acid Binding Protein 4... |
| Anwendung: | Cell-permeable, potent FABP4 inhibitor |
| CAS | 300657-03-8 |
| MW: | 474.6 D |
ab 60,00 €
SAG
Artikelnummer: Cay11914-1
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...
| Schlagworte: | Smoothened Agonist,... |
| Anwendung: | Smo Agonist |
| CAS | 912545-86-9 |
| MW: | 490.1 D |
ab 48,00 €
Prostaglandin E1
Artikelnummer: Cay13010-1
Prostaglandin E1 (PGE1) is a vasoactive prostaglandin and an active metabolite of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2 (Cay-14010) receptor subtypes EP1, EP2, EP3, and EP4, and the IP receptor (Kis = 36, 10, 1.1, 2.1, and 33 nM,...
| Schlagworte: | Alprostadil, PGE1, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 745-65-3 |
| MW: | 354.5 D |
ab 30,00 €
Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 77,00 €
15-keto Prostaglandin E1
Artikelnummer: Cay13680-1
15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.Formal Name: (11alpha,13E)-11-hydroxy-9,15-dioxo-prost-13-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5....
| Schlagworte: | 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 22973-19-9 |
| MW: | 352.5 D |
ab 88,00 €
Prostaglandin I2 (sodium salt)
Artikelnummer: Cay18220-1
Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...
| Schlagworte: | Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt |
| Anwendung: | Bioactive lipid assays |
| CAS | 61849-14-7 |
| MW: | 374.5 D |
ab 98,00 €