TRMP2-HEK293 Recombinant Cell Line

Recombinant HEK293 cell line expressing tetracycline-inducible human TRPM2 (transient receptor potential cation channel, subfamily M, member 2, accession number NM_003307). TRPM2 channel belongs to the transient receptor potential channel (TRP) superfamily which is divided into seven main subfamilies. TRPM2 channel is a nonselective, calciumpermeable cation channel highly expressed in the brain, vascular smooth muscle, endothelial cells and immune cells. It is activated by oxidative stressors such as hydrogen peroxide, cyclic ADP ribose, and NADP, leading to an increase in the intracellular free calcium concentration and cell death. TRPM2 is a potential drug target in a variety of human diseases, including cardiovascular and neurodegenerative diseases.