Spike (B.1.618 Variant) Pseudotyped Lentivirus (Luc Reporter)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
BPS-78206-1 100 µl - -

3 - 15 Werktage*

1.223,00 €
BPS-78206-2 1 ml (500 µl x 2) - -

3 - 15 Werktage*

5.762,00 €
 
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome... mehr
Produktinformationen "Spike (B.1.618 Variant) Pseudotyped Lentivirus (Luc Reporter)"
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. A variant called B.1.618 was identified in India in the spring of 2021. This variant has a number of mutations that allow the virus to spread more easily and quickly than other variants.   The Spike (B.1.618 Variant) (SARS-CoV-2) Pseudotyped Lentivirus were produced with SARS-CoV-2 B.1.618 Variant Spike (Genbank Accession #QHD43416.1 with B.1.618 mutations, see below for details) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions contain the firefly luciferase gene driven by a CMV promoter (Figure 1), therefore, the spike-mediated cell entry can be measured via luciferase activity. The Spike (B.1.618 Variant) (SARS-CoV-2) pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 B.1.618 variant in a Biosafety Level 2 facility.   Spike Mutations in B.1.618 Variant: Y145del H146del E484K D614G
Schlagworte: 2,
Hersteller: BPS Bioscience
Hersteller-Nr: 78206

Eigenschaften

Anwendung: Coronavirus studies
Spezies-Reaktivität: SARS-CoV-2

Handhabung & Sicherheit

Lagerung: -80°C (-70 °C for long term storage)
Versand: -80°C (International: °C)
Achtung
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