Multi-Drug Resistance Assay Kit (Calcein AM)

Multi-Drug Resistance Assay Kit (Calcein AM)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay600370-1000 1000 tests - -

1 - 10 Werktage

282,00 €
 
P-Glycoprotein (P-gp), the product of the multidrug resistance (MDR) gene MDR1, and multidrug... mehr
Produktinformationen "Multi-Drug Resistance Assay Kit (Calcein AM)"
P-Glycoprotein (P-gp), the product of the multidrug resistance (MDR) gene MDR1, and multidrug resistance associated proteins (MRP) are members of the superfamiliy of ATP-binding cassette (ABC) transporters. They are localized in the luminal membrane of endothelial cells and function to detoxify or eliminate a spectrum of harmful agents and chemicals by mediating energy-dependent transport from the cell. While their expression in normal cells protects the cells from xenobiotic attack, their expression in other cells, such as cancer cells, can be a significant obstacle to drug efficacy. Cayman's Multidrug Resistance Assay Kit provides a convenient tool for studying MDR protein modulators. The kit employs calcein AM, a substrate for MDR proteins including P-gp and MRP, as a probe for the detection of chemical compounds interacting with MDR proteins. Hoechst Dye is used as a marker of cell nuclei. Cyclosporin A, a competitive inhibitor, and verapamil, a noncompetitive inhibitor, are included as positive controls.
Schlagworte: MDR
Hersteller: Cayman Chemical
Hersteller-Nr: 600370-1000

Eigenschaften

Anwendung: MDR protein modulator studies
Format: Homog.

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
GHS-Piktogramme:
H-Sätze: H301, H302, H311, H315, H319, H331
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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