CYP2C9 Induction Reporter Assay Kit

CYP2C9 Induction Reporter Assay Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay601120-1 100 tests -

6 - 10 Werktage*

621,00 €
 
Early screening of drug candidate's potential to induce or inhibit CYP2C9 is a critical step in... mehr
Produktinformationen "CYP2C9 Induction Reporter Assay Kit"
Early screening of drug candidate's potential to induce or inhibit CYP2C9 is a critical step in the drug development process. The CYP2C9 Induction Reporter Assay Kit is a novel method to evaluate CYP2C9 induction by drug candidates. Cayman's CYP2C9 Induction Reporter Assay Kit consists of a 96-well plate coated with a transfection complex containing a Secreted Alkaline Phosphatase (SEAP) reporter regulated by the human CYP2C9 gene promoter. Cells grown on the CYP2C9 Reporter Reverse Transfection Strip Plate will introduce the reporter gene and express GRalpha as well as HNF4alpha. Test compounds that promote binding of the nuclear receptors to the CYP2C9 promoter initiates SEAP expression. SEAP activity is subsequently measured using a luminescence readout. The kit is simple to use and can be easily adapted to high-throughput screening for potential nuclear receptor-mediated CYP2C9 inducers.
Schlagworte: CYP2C9, CYP2C10, CYPIIC9, EC=1.14.13.-, EC=1.14.13.48, EC=1.14.13.80, EC=1.14.13.49, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, S-mephenytoin 4-hydroxylase, (R)-limonene 6-monooxygenase
Hersteller: Cayman Chemical
Hersteller-Nr: 601120

Eigenschaften

Anwendung: Reverse transfection reporter assay
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H227, H315, H317, H319, H334
P-Sätze: P210, P261, P264, P272, P280, P284, P302+352, P304+341, P305+351+338, P321, P332+313, P333+313, P337+313, P342+311, P362+364, P370+378, P403, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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