Prostaglandin E Metabolite ELISA Kit

Prostaglandin E Metabolite ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay514531-96S 96 so-wells (96 solid wells) -

6 - 10 Werktage*

428,00 €
Cay514531-96 96 st-wells (96 strip wells) -

6 - 10 Werktage*

428,00 €
Cay514531-480 480 st-wells (480 strip wells) -

6 - 10 Werktage*

1.599,00 €
Cay514531-480S 480 so-wells (480 solid wells) -

6 - 10 Werktage*

1.599,00 €
 
Prostaglandin E2 (PGE2) is produced by a variety of cell types which, in general, do not contain... mehr
Produktinformationen "Prostaglandin E Metabolite ELISA Kit"
Prostaglandin E2 (PGE2) is produced by a variety of cell types which, in general, do not contain the enzymes required for metabolism of PGE2. Thus, cultured endothelial cells or osteoblasts will release PGE2 into the culture medium, where it will accumulate without appreciable metabolism. The direct assay of PGE2 from the medium is a good way to measure PGE2 production from these cells. PGE2 is rapidly converted in vivo to its 13,14-dihydro-15-keto metabolite, with more than 90% of circulating PGE2 cleared by a single passage through the lungs. Unfortunately, this metabolite is not chemically stable and undergoes a variable amount of degradation to PGA products. For this reason, blood, urine, or other samples from whole animals or humans often contain very little intact PGE2, and measurement of the metabolites is necessary to provide a reliable estimate of actual PGE2 production. Cayman's PGE Metabolite assay was developed as a method of converting 13,14-dihydro-15-keto PGA2 and 13,14-dihydro-15-keto PGE2 to a single, stable derivative that could be easily quantified by ELISA. This assay is therefore the method of choice if the samples in question have undergone extensive metabolism prior to collection.Synonyms: PGE Metabolite EIA Kit, PGEM. Assay Range: 0.39-50 pg/ml. Sensitivity: 80% B/B0: ~2 pg/ml. Mid-point: 50% B/B0: ~8-14 pg/ml. Cross Reactivity: (13,14-dihydro-15-keto Prostaglandin E1 (derivatized)) 100%, (13,14-dihydro-15-keto Prostaglandin E2 (derivatized)) 100%, (Bicyclo Prostaglandin E1) 38%, (13,14-dihydro-15-keto Prostaglandin D2 (derivatized)) 0.08%, (13,14-dihydro-15-keto Prostaglandin F2alpha (derivatized)) 0.02%, (Arachidonic Acid) <0.01%, (Leukotriene B4) <0.01%, (tetranor-PGEM) <0.01%, (tetranor-PGFM) <0.01%, (Prostaglandin D2) <0.01%, (Prostaglandin E1) <0.01%, (6-keto Prostaglandin E1) <0.01%, (Prostaglandin E2) <0.01%, (Prostaglandin F1alpha) <0.01%, (6-keto Prostaglandin F1alpha) <0.01%, (Prostaglandin F2alpha) <0.01%, (Thromboxane B2) <0.01%. Origin: Animal/Mouse, Animal/Bovine, Animal/Eel, Animal/Rabbit.
Schlagworte: PGE Metabolite EIA Kit, PGEM
Hersteller: Cayman Chemical
Hersteller-Nr: 514531

Eigenschaften

Anwendung: ELISA
Format: Solid Phase

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H301, H302, H311, H315, H318, H319, H335, H350, H373
P-Sätze: P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P303+361+353, P304+340, P305+351+338, P308+313, P310, P312, P314, P321, P330, P332+313, P337+313, P361+364, P362+364, P370+378, P403+233, P403+235, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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