Mouse VEGFR2 - KDR ELISA Kit

Mouse VEGFR2 - KDR ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0360 1 kit - -

6 - 10 Werktage*

920,00 €
 
Natural and recombinant mouse VEGFR2. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Mouse VEGFR2 - KDR ELISA Kit"
Natural and recombinant mouse VEGFR2. There is no detectable cross-reactivity with other relevant proteins. Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC- mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. [The UniProt Consortium]
Schlagworte: Kdr, FLK-1, Flk-1, CD309, VEGFR-2, Kinase NYK, EC=2.7.10.1, Fetal liver kinase 1, Protein-tyrosine kinase receptor flk-1, Vascular endothelial growth factor receptor 2
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0360

Eigenschaften

Anwendung: ELISA
Wirt: Mouse
Spezies-Reaktivität: mouse
Immunogen: Expression system for standard: NSO, Immunogen sequence: A20-E762
Format: Solid Phase

Datenbank Information

UniProt ID : P35918 | Passende Produkte
Gene ID GeneID 16542 | Passende Produkte

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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