Mouse TNPO1 (Transportin 1) ELISA Kit

Mouse TNPO1 (Transportin 1) ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-EL-M1197.96 96 wells - -

7 - 16 Werktage

587,00 €
 
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of TNPO1 in serum,... mehr
Produktinformationen "Mouse TNPO1 (Transportin 1) ELISA Kit"
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of TNPO1 in serum, plasma and other biological fluids. Detection Range: 1.56--100ng/mL. Sensitivity: 0.94ng/mL. Protein function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of SRP19. Mediates the import of histones H2A, H2B, H3 and H4 (PubMed:11493596). Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner. [The UniProt Consortium]
Schlagworte: Kpnb2, Tnpo1, Transportin-1, Importin beta-2, Karyopherin beta-2
Hersteller: Elabscience
Hersteller-Nr: E-EL-M1197

Eigenschaften

Anwendung: ELISA
Reaktivität: Mouse
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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