Human TGF beta 1 ELISA Kit

Human TGF beta 1 ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0307 1 kit - -

6 - 10 Werktage*

848,00 €
 
Natural and recombinant human TGF beta1. There is no detectable cross-reactivity with other... mehr
Produktinformationen "Human TGF beta 1 ELISA Kit"
Natural and recombinant human TGF beta1. There is no detectable cross-reactivity with other relevant proteins. Protein function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292). [The UniProt Consortium]
Schlagworte: TGFB, TGFB1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0307

Eigenschaften

Anwendung: ELISA
Wirt: Human
Spezies-Reaktivität: human
Immunogen: Expression system for standard: CHO, Immunogen sequence: A279-S390
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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