Human sRANK Ligand / TNFSF11 / TRANCE ELISA Kit

Human sRANK Ligand / TNFSF11 / TRANCE ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG80183.96 96 wells -

6 - 14 Werktage*

638,00 €
 
Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast... mehr
Produktinformationen "Human sRANK Ligand / TNFSF11 / TRANCE ELISA Kit"
Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. [The UniProt Consortium]
Schlagworte: Anti-OPGL, Anti-TNFSF11
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG80183

Eigenschaften

Anwendung: ELISA
Spezies-Reaktivität: human
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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