Human S100A12 (S100 Calcium Binding Protein A12) ELISA Kit

Human S100A12 (S100 Calcium Binding Protein A12) ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-EL-H1293.96 96 wells - -

7 - 16 Werktage

587,00 €
 
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of S100A12 in... mehr
Produktinformationen "Human S100A12 (S100 Calcium Binding Protein A12) ELISA Kit"
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of S100A12 in serum, plasma and other biological fluids. Detection Range: 0.16--10ng/mL. Sensitivity: 0.1ng/mL. Protein function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. [The UniProt Consortium]
Schlagworte: S100A12
Hersteller: Elabscience
Hersteller-Nr: E-EL-H1293

Eigenschaften

Anwendung: ELISA
Reaktivität: Human
Format: Solid Phase

Datenbank Information

UniProt ID : P80511 | Finde Alternativen
Gene ID GeneID 6283 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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