Human IL-1R1(Interleukin 1 Receptor Type I) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of IL-1R1 in serum, plasma and other biological fluids. Detection Range: 0.16--10ng/mL. Sensitivity: 0.1ng/mL. Protein function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. [The UniProt Consortium]