Human HVEM / TR2 ELISA Kit

Human HVEM / TR2 ELISA Kit
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Angebot
Aktion:

Bestellen Sie jetzt ELISA-Kits von Arigo Biolaboratories mit 20% Rabatt.

*1
*1 Angebot gültig bis zum 31.12.2020
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
ARG81855.96 96 wells - -

6 - 14 Werktage

20 %
805,00 €
644,00 €
 
Protein function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT... mehr
Produktinformationen "Human HVEM / TR2 ELISA Kit"
Protein function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines. Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). [The UniProt Consortium]
Schlagworte: TR2, HVEA, HveA, CD270, Herpesvirus entry mediator A, Herpes virus entry mediator A, Tumor necrosis factor receptor-like 2, Tumor necrosis factor receptor superfamily member 14
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG81855096

Eigenschaften

Anwendung: ELISA
Reaktivität: Human
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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