Human EGFR (Epidermal Growth Factor Receptor) CLIA Kit

Human EGFR (Epidermal Growth Factor Receptor) CLIA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-HUES00058.96 96 assays -

9 - 20 Werktage*

694,00 €
 
ELISA Type: CLIA. Sensitivity: 46.875 pg/mL. Range: 78.125--5000 pg/mL. Protein function:... mehr
Produktinformationen "Human EGFR (Epidermal Growth Factor Receptor) CLIA Kit"
ELISA Type: CLIA. Sensitivity: 46.875 pg/mL. Range: 78.125--5000 pg/mL. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK- ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Schlagworte: ERBB, EGFR, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1
Hersteller: Assay Genie
Hersteller-Nr: HUES00058

Eigenschaften

Anwendung: CLIA
Spezies-Reaktivität: human
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: +4°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319
P-Sätze: P264, P280
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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