Human EGFR ELISA Kit

Human EGFR ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0158 1 kit - -

6 - 10 Werktage*

848,00 €
 
Natural and recombinant human EGFR. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human EGFR ELISA Kit"
Natural and recombinant human EGFR. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]
Schlagworte: ERBB, EGFR, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0158

Eigenschaften

Anwendung: ELISA
Wirt: Human
Spezies-Reaktivität: human
Immunogen: Expression system for standard: NSO, Immunogen sequence: M1-S645
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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