CD130 (human) ELISA Kit

CD130 (human) ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
DC-850.520.048 48 wells (1 x 48 Discovery (pre-coated))

3 - 8 Werktage*

197,00 €
DC-850.520.096 96 wells (1 x 96 (pre-coated))

3 - 8 Werktage*

386,00 €
DC-850.520.192 192 wells (2 x 96 (pre-coated))

3 - 8 Werktage*

618,00 €
 
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards,... mehr
Produktinformationen "CD130 (human) ELISA Kit"
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents, and a detailed procedure., Assay Range: 56.25-1800 pg/ml, Sensitivity: 15 pg/ml, Cross reaction: No cross reactivity with other human soluble receptors. No interference with neither soluble gp80 nor IL-6., Incubation time: 1h40, Sample Types: Serum, Plasma, Cell culture supernatant, Sample Size: 100 µl Protein function: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes- associated protein 1 (YAP) and NOTCH pathways to control inflammation- induced epithelial regeneration, independently of STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. [The UniProt Consortium]
Schlagworte: Human CD130 ELISA Kit, gp130, CD130, gp130, IL-6RB, CDw130, IL-6R-beta, IL-6R subunit beta, Membrane glycoprotein 130, IL-6 receptor subunit beta, Interleukin-6 signal transducer, Oncostatin-M receptor subunit alpha, Interleukin-6 receptor subunit beta
Hersteller: Diaclone
Hersteller-Nr: 850.520

Eigenschaften

Anwendung: ELISA
Spezies-Reaktivität: human
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +20°C (International: +20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H300, H302, H310, H314, H315, H317, H318, H319, H335, H360, H400, H410, EUH032
P-Sätze: P201, P202, P260, P261, P262, P264, P270, P271, P272, P273, P280, P312, P321, P363, P391, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P332+P313, P333+P313, P337+P313, P361+P364, P362+P364, P405, P403+P233, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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