Canine IL10 ELISA Kit

Canine IL10 ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG82642.96 96 wells -

6 - 14 Werktage*

1.360,00 €
 
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system... mehr
Produktinformationen "Canine IL10 ELISA Kit"
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Schlagworte: CSIF, IL10, IL-10, Interleukin-10, Cytokine synthesis inhibitory factor
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG82642

Eigenschaften

Anwendung: ELISA
Spezies-Reaktivität: dog
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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