Nrf2 Transcription Factor Assay Kit

Nrf2 Transcription Factor Assay Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay600590-96 96 wells -

5 - 10 Werktage*

532,00 €
 
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in... mehr
Produktinformationen "Nrf2 Transcription Factor Assay Kit"
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for degradation by proteasomes. Under oxidative stress, Nrf2 is released from the Nrf2/Keap1 complex and translocates to the nucleus where it is able to induce the expression of a battery of genes encoding diverse cytoprotective proteins, including antioxidative enzymes, anti-inflammatory mediators, and proteasomes. Cayman's Nrf2 Transcription Factor Assay is a non-radioactive, colorimetric method for detecting specific transcription factor DNA binding activity in nuclear extracts. A specific double stranded DNA (dsDNA) sequence containing the Nrf2 response element is immobilized onto the wells of a 96-well plate. Nrf2 contained in nuclear extract samples will bind specifically to the Nrf2 response element and can be detected by addition of a specific Nrf2 antibody and a secondary antibody conjugated to HRP. Synonyms: GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2.
Schlagworte: GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2
Hersteller: Cayman Chemical
Hersteller-Nr: 600590

Eigenschaften

Anwendung: DNA binding assay
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H227, H302, H303, H313, H314, H315, H316, H317, H318, H319, H334, H335, H412
P-Sätze: P210, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+310, P301+330+331, P302+352, P303+361+353, P304+340, P304+341, P305+351+338, P310, P312, P321, P330, P332+313, P333+313, P337+313, P342+311, P362+364, P363, P370+378, P403, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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