Anti-phospho-RBL1 (Ser975) (RB-like 1, Retinoblastoma-like Protein 1, 107kD Retinoblastoma-associate

Anti-phospho-RBL1 (Ser975) (RB-like 1, Retinoblastoma-like Protein 1, 107kD Retinoblastoma-associate
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
R1200-49-Biotin.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1... mehr
Produktinformationen "Anti-phospho-RBL1 (Ser975) (RB-like 1, Retinoblastoma-like Protein 1, 107kD Retinoblastoma-associate"
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-phospho-p107, Anti-phospho-RBL1, Anti-phospho-pRb1, Anti-phospho-Retinoblastoma-like protein 1, Anti-phospho-107 kDa retinoblastoma-associated protein
Hersteller: United States Biological
Hersteller-Nr: R1200-49-Biotin

Eigenschaften

Anwendung: ELISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: Biotin
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser975 of human Rb-like 1 (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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