Anti-phospho-NFkB p65 (Thr505)

Anti-phospho-NFkB p65 (Thr505)
Anti-phospho-NFkB p65 (Thr505)

Sichern Sie sich jetzt 20% Rabatt auf Arigo Inflammation Research Tools

*1 Angebot gültig bis zum 31.12.2021
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
ARG51664.50 50 µl - -

6 - 14 Werktage*

20 %
351,00 €
280,80 €
ARG51664.100 100 µl - -

6 - 14 Werktage*

20 %
505,00 €
404,00 €
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell... mehr
Produktinformationen "Anti-phospho-NFkB p65 (Thr505)"
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). [The UniProt Consortium]
Schlagworte: Anti-phospho-RELA, Anti-phospho-NFKB3, Anti-phospho-Transcription factor p65, Anti-phospho-Nuclear factor NF-kappa-B p65 subunit, Anti-phospho-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG51664


Anwendung: WB, IHC (paraffin)
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of threonine 505 (L-V-T(p)-G-A) derived from Human NFkappaB-p65
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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