Anti-phospho-ERBB2 (Tyr1196) (ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2,

Anti-phospho-ERBB2 (Tyr1196) (ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2,
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
035184.200 200 µl - -

3 - 19 Werktage*

728,00 €
 
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor... mehr
Produktinformationen "Anti-phospho-ERBB2 (Tyr1196) (ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2,"
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot blot 1:500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-phospho-HER2, Anti-phospho-CD340, Anti-phospho-ERBB2, Anti-phospho-MLN 19, Anti-phospho-p185erbB2, EC=2.7.10.1, Anti-phospho-Proto-oncogene Neu, Anti-phospho-Proto-oncogene c-ErbB-2, Anti-phospho-Metastatic lymph node gene 19 protein
Hersteller: United States Biological
Hersteller-Nr: 035184

Eigenschaften

Anwendung: ELISA, Dot Blot
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1196 of human ERBB2.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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