Anti-phospho-EGFR (Tyr992) Monoclonal Antibody (Clone:EM-12)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-30-1399-0.1 100 µg -

3 - 11 Werktage*

654,00 €
 
The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member... mehr
Produktinformationen "Anti-phospho-EGFR (Tyr992) Monoclonal Antibody (Clone:EM-12)"
The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Schlagworte: Anti-phospho-ERBB, Anti-phospho-EGFR, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1, Anti-EGFR (Phospho-Tyr992) Monoclonal Antibody (Clone:EM-12)
Hersteller: Abeomics
Hersteller-Nr: 30-1399

Eigenschaften

Anwendung: FC, IP, WB
Antikörper-Typ: Monoclonal
Klon: EM-12
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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