Anti-phospho-EGFR (Tyr1172)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F48508-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F48508-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Epidermal Growth factor receptor (EGFR) is the... mehr
Produktinformationen "Anti-phospho-EGFR (Tyr1172)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. EGFR is a receptor for EGF, but also for other members of the EGF family, including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]
Schlagworte: Anti-phospho-EGFR, Anti-phospho-ERBB, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1, Phospho-EGFR Antibody (pY1172)
Hersteller: NSJ Bioreagents
Hersteller-Nr: F48508

Eigenschaften

Anwendung: WB, Dot Blot, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: This phospho-EGFR antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1172 of human EGFR.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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