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Anti-phospho-EGF Receptor / EGFR (Ser695), clone GCC-5

Anti-phospho-EGF Receptor / EGFR (Ser695), clone GCC-5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-RQ4839 100 µg - -

3 - 10 Werktage

549,00 €
 
Antibody in PBS with 0.02% sodium azide and 50% glycerol. EGFR is a receptor tyrosine kinase.... mehr
Produktinformationen "Anti-phospho-EGF Receptor / EGFR (Ser695), clone GCC-5"
Antibody in PBS with 0.02% sodium azide and 50% glycerol. EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Schlagworte: Anti-phospho-EGFR, Anti-phospho-ERBB, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1, Phospho-EGF Receptor / EGFR Antibody (pS695)
Hersteller: NSJ Bioreagents
Hersteller-Nr: RQ4839

Eigenschaften

Anwendung: WB
Antikörper-Typ: Monoclonal
Klon: GCC-5
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: A synthetic peptide specific to human EGFR (surrounding pS695)
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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