Anti-phospho-ATM Protein Kinase (Ser1981)

Anti-phospho-ATM Protein Kinase (Ser1981)
Anti-phospho-ATM Protein Kinase (Ser1981)
   
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
600-601-400S 25 µl - -

1 - 9 Werktage

132,00 €
600-601-400 100 µg - -

1 - 9 Werktage

493,00 €
 
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... mehr
Produktinformationen "Anti-phospho-ATM Protein Kinase (Ser1981)"

Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. [The UniProt Consortium]

Schlagworte: Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia telangiectasia mutated
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 600-601-400S

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Sheep
Reaktivität: Human
Immunogen: synthetic phospho-peptide corresponding to a region near serine 1981 of human ATM

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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