Anti-phospho-AKT1 (Ser129) (RAC-alpha Serine/Threonine-protein Kinase, RAC-PK-alpha, Protein Kinase

Anti-phospho-AKT1 (Ser129) (RAC-alpha Serine/Threonine-protein Kinase, RAC-PK-alpha, Protein Kinase
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A1125-11B-FITC.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in... mehr
Produktinformationen "Anti-phospho-AKT1 (Ser129) (RAC-alpha Serine/Threonine-protein Kinase, RAC-PK-alpha, Protein Kinase"
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Applications: Suitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-phospho-PKB, Anti-phospho-AKT1, Anti-phospho-PKB alpha, EC=2.7.11.1, Anti-phospho-RAC-PK-alpha, Anti-phospho-Protein kinase B, Anti-phospho-Proto-oncogene c-Akt, Anti-phospho-Protein kinase B alpha
Hersteller: United States Biological
Hersteller-Nr: A1125-11B-FITC

Eigenschaften

Anwendung: FLISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: FITC
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser129 of human AKT1 (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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