Anti-phospho-ABL (Tyr412) (p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolo

Anti-phospho-ABL (Tyr412) (p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolo
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
031502-FITC.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been... mehr
Produktinformationen "Anti-phospho-ABL (Tyr412) (p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolo"
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. Applications: Suitable for use in Dot Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-phospho-ABL, Anti-phospho-ABL1, Anti-phospho-p150, EC=2.7.10.2, Anti-phospho-Proto-oncogene c-Abl, Anti-phospho-Tyrosine-protein kinase ABL1, Anti-phospho-Abelson tyrosine-protein kinase 1
Hersteller: United States Biological
Hersteller-Nr: 031502-FITC

Eigenschaften

Anwendung: FLISA, Dot Blot, WB
Antikörper-Typ: Polyclonal
Konjugat: FITC
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Phospho-ABL-Y412 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human ABL.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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